The relationship between axonal transport of protein and demyelination in the optic nerves of mice infected with Semliki Forest Virus
Identifieur interne : 001610 ( Main/Exploration ); précédent : 001609; suivant : 001611The relationship between axonal transport of protein and demyelination in the optic nerves of mice infected with Semliki Forest Virus
Auteurs : E. M. Tansey [Royaume-Uni] ; Hisako Ikeda [Royaume-Uni]Source :
- Brain Research [ 0006-8993 ] ; 1986.
English descriptors
- Teeft :
- Avirulent semliki forest virus, Axon, Axonal, Axonal transport, Axoplasmic flow, Bap, Cerebrospinal fluid, Colliculus, Control mice, Demyelinating, Demyelination, Fibre, Histogram, Inoculation, Intravitreal, Intravitreal injection, Intravitreal injections, Ipsilateral counts, Liquid scintillation, Mouse, Myelin, Myelin sheath, Open circles, Optic, Optic nerve, Optic nerve fibres, Optic nerve terminals, Optic nerves, Radioactivity, Retina, Retinal ganglion cells, Scintillation, Semliki, Semliki forest virus, Slow axonal transport, Superior colliculus, Webb.
Abstract
Abstract: Fast and slow axonal transport of protein have been studied in the optic nerves of mice infected with Semliki Forest Virus (SFV) that causes patchy demyelination throughout the CNS. Intravitreal injections of [3H]proline were given at regular intervals after virus inoculation, the labelled protein in the superior colliculi was then measured after survival periods of 18 h or 10 days, for fast and slow axonal transport studies, respectively. Fast transport studies showed an enhanced amount of protein arriving at the optic nerve terminals (superior colliculus) of the SFV-infected mice prior to the onset of demyelination. In contrast, the slow transport studies showed an enhanced amount of protein at the superior colliculus of the SFV-infected mice during the demyelination period. There was no concomitant increase in labelled protein in the retina at any time after the SFV infection. It is proposed that alteration in the transport of the protein constituents other than major myelin specific components may cause disruption of myelin maintenance in SFV infection.
Url:
DOI: 10.1016/0006-8993(86)91364-8
Affiliations:
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M." last="Tansey">E. M. Tansey</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Vision Research Unit of the Sherrington School, The Rayne Institute, St. Thomas' Hospital, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Ikeda, Hisako" sort="Ikeda, Hisako" uniqKey="Ikeda H" first="Hisako" last="Ikeda">Hisako Ikeda</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Vision Research Unit of the Sherrington School, The Rayne Institute, St. Thomas' Hospital, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Brain Research</title><title level="j" type="abbrev">BRES</title><idno type="ISSN">0006-8993</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1986">1986</date><biblScope unit="volume">397</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="9">9</biblScope><biblScope unit="page" to="15">15</biblScope></imprint><idno type="ISSN">0006-8993</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0006-8993</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Avirulent semliki forest virus</term><term>Axon</term><term>Axonal</term><term>Axonal transport</term><term>Axoplasmic flow</term><term>Bap</term><term>Cerebrospinal fluid</term><term>Colliculus</term><term>Control mice</term><term>Demyelinating</term><term>Demyelination</term><term>Fibre</term><term>Histogram</term><term>Inoculation</term><term>Intravitreal</term><term>Intravitreal injection</term><term>Intravitreal injections</term><term>Ipsilateral counts</term><term>Liquid scintillation</term><term>Mouse</term><term>Myelin</term><term>Myelin sheath</term><term>Open circles</term><term>Optic</term><term>Optic nerve</term><term>Optic nerve fibres</term><term>Optic nerve terminals</term><term>Optic nerves</term><term>Radioactivity</term><term>Retina</term><term>Retinal ganglion cells</term><term>Scintillation</term><term>Semliki</term><term>Semliki forest virus</term><term>Slow axonal transport</term><term>Superior colliculus</term><term>Webb</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Fast and slow axonal transport of protein have been studied in the optic nerves of mice infected with Semliki Forest Virus (SFV) that causes patchy demyelination throughout the CNS. Intravitreal injections of [3H]proline were given at regular intervals after virus inoculation, the labelled protein in the superior colliculi was then measured after survival periods of 18 h or 10 days, for fast and slow axonal transport studies, respectively. Fast transport studies showed an enhanced amount of protein arriving at the optic nerve terminals (superior colliculus) of the SFV-infected mice prior to the onset of demyelination. In contrast, the slow transport studies showed an enhanced amount of protein at the superior colliculus of the SFV-infected mice during the demyelination period. There was no concomitant increase in labelled protein in the retina at any time after the SFV infection. It is proposed that alteration in the transport of the protein constituents other than major myelin specific components may cause disruption of myelin maintenance in SFV infection.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li></region><settlement><li>Londres</li></settlement></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Tansey, E M" sort="Tansey, E M" uniqKey="Tansey E" first="E. M." last="Tansey">E. M. Tansey</name></region><name sortKey="Ikeda, Hisako" sort="Ikeda, Hisako" uniqKey="Ikeda H" first="Hisako" last="Ikeda">Hisako Ikeda</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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